Anti-Carcinogenesis of CBD

There have been 113 Cannabinoids identified and many of them display anti-carcinogenic activity through inhibiting processes like angiogenesis , metastasis, and inflammation.

1) “A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells”

N.M. Kogan (2006)

Click to access mol.105.021089.full.pdf

2) “Cannabidiol inhibits angiogenesis by multiple mechanisms”

https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.2012.02050.x

3) “GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268199/

“Role of the lysophosphatidylinositol/GPR55 axis in cancer.”

https://www.ncbi.nlm.nih.gov/pubmed/26588872

4) “Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.”

https://www.ncbi.nlm.nih.gov/pubmed/24373545

5) “Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents.”

https://www.ncbi.nlm.nih.gov/pubmed/23079154

6) “Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.”

https://www.ncbi.nlm.nih.gov/pubmed/22231745

7) “Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs”

https://www.ncbi.nlm.nih.gov/pubmed/29867351

8) “Cannabinoids as Anticancer Drugs.”

https://www.ncbi.nlm.nih.gov/pubmed/28826542

9) “Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas.”

https://www.ncbi.nlm.nih.gov/pubmed/27633508

10) “The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids.”

11) “The combination of cannabidiol and Δ9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model.”

https://www.ncbi.nlm.nih.gov/pubmed/25398831

12) “A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells.”

https://www.ncbi.nlm.nih.gov/pubmed/16571653

13) “HU-331: a cannabinoid quinone, with uncommon cytotoxic properties and low toxicity.” (It displayed little toxicity while exerting anti-angiogenic effects and inducing apoptosis.)

https://www.ncbi.nlm.nih.gov/pubmed/17714026

14) “Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme.”

https://www.ncbi.nlm.nih.gov/pubmed/23349970

15) “Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect.”

https://www.ncbi.nlm.nih.gov/pubmed/24204703

16) “Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells.”

https://www.ncbi.nlm.nih.gov/pubmed/24976505

17) “5‐Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non‐psychoactive cannabinoid”

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2007.05073.x

18) “Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells”

https://www.sciencedirect.com/science/article/abs/pii/S0006295214003608

19) Blockade of cannabinoid receptors reduces inflammation, leukocyte accumulation and neovascularization in a model of sponge-induced inflammatory angiogenesis”

https://link.springer.com/article/10.1007/s00011-013-0638-8

20) “Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma”

http://jpet.aspetjournals.org/content/318/3/1375.short

21) “Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1”

https://www.fasebj.org/doi/abs/10.1096/fj.11-198184

22) “Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death”

http://jpet.aspetjournals.org/content/328/3/708.short

23) “Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats*”

https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.25625

24) “Cannabidiol can be potentially considered as an anti-colon cancer medicine as it exerts an inhibitory effect on angiogenesis, tumor growth, and metastasis through reducing VEGF gene expression, decreasing excessive cytokines, and increasing antioxidant enzyme activities.” (All of these effects are inhibitory of all kinds of cancers, not solely colon. Tumors need an environment with scarce antioxidants (low pH and blood cell aggregation), full of inflammatory cytokines, and they need the VEGF gene expressed and a some other conditions like excessive methionine in order to supply themselves with new blood vessels to acquire food for growth.)

https://link.springer.com/article/10.1007/s00580-018-2810-6

25) “Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells”

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1280-0

26) “Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines”

https://www.sciencedirect.com/science/article/pii/S0960977618301218

27) “Cannabidiol as an Antioxidant”

https://www.sciencedirect.com/science/article/pii/B9780128007563000934

28) “Cannabidiol and Cancer — An Overview of the Preclinical Data”

https://www.intechopen.com/books/molecular-considerations-and-evolving-surgical-management-issues-in-the-treatment-of-patients-with-a-brain-tumor/cannabidiol-and-cancer-an-overview-of-the-preclinical-data

29) “Cannabidiol hydroxyquinone-induced apoptosis of splenocytes is mediated predominantly by thiol depletion”

https://www.sciencedirect.com/science/article/pii/S0378427410000895

30) “Delta9‐tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: A critical examination of the preclinical literature”

https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/cpt.84

31) “Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells”

http://ar.iiarjournals.org/content/35/11/5827.short

32) “Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells”

33) “Cannabidiol stimulates Aml‐1a‐dependent glial differentiation and inhibits glioma stem‐like cells proliferation by inducing autophagy in a TRPV2‐dependent manner”

https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.29573

34) “Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells”

https://www.sciencedirect.com/science/article/pii/S0024320515003598

35) “CYCLOOXYGENASE-2 AND PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR γ CONFER CANNABIDIOL-INDUCED APOPTOSIS OF HUMAN LUNG CANCER CELLS”

http://mct.aacrjournals.org/content/early/2012/11/28/1535-7163.MCT-12-0335.short

36) “Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor‐independent mechanism” “These results reinforce the evidence of antitumoral properties of CBD”

https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1038/sj.bjp.0706134

37) “Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid”

https://academic.oup.com/carcin/article/35/12/2787/335166

38) “Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis”

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028159

39) “Cannabidiol induces programmed cell death in breast cancer cells by coordinating the crosstalk between apoptosis and autophagy”

http://mct.aacrjournals.org/content/early/2011/05/10/1535-7163.MCT-10-1100.short

40) “Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis”

https://link.springer.com/article/10.1007/s10549-010-1177-4

41) “Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti‐tumor mechanisms of Cannabidiol in breast cancer”